BUILD THE FUTURE WITH US
Hard Problems. Real capital. No apologies.
Great Problems Give Rise to Great Markets.
Great Problems Give Rise
to Great Markets.
This is a defining moment of global strategic competition—driven by accelerating revolutions in science and technology. It will be shaped not only by innovators, but by the investors who stand behind them.
Portfolio
Team
Brian Wilcove
Managing Partner
Gilman Louie
Managing Partner
Jeff Karras
General Partner
Adam Hammer
General Partner
Steve Weinstein
General Partner
Mike Mettler
General Partner
Marianne Winkler
CFO & General Partner
Kevin McGinnis
Partner
John Watters
Venture Partner
Aneesh Mdhekar
Analyst
Sabrina Rosahan
Executive Direcor, AFF
Brian Connor
Operations Manager
Brian Wilcove
Managing Partner
Gilman Louie
Managing Partner
Jeff Karras
General Partner
Steve Weinstein
General Partner
Mike Mettler
General Partner
Marianne Winkler
CFO & General Partner
Kevin McGinnis
Partner
John Watters
Venture Partner
Aneesh Mdhekar
Analyst
Sabrina Rosahan
Executive Direcor, AFF
Brian Connor
Operations Manager
Sectors
Compute
Compute
Not another application—the foundation. Microelectronics, infrastructure, networks, the stack on which everything depends. Applications draw attention. The foundation holds the power.
Biology
Biology
Beyond a single outcome, to the system beneath it. The greatest value lies not in the application, but in the platform that makes it possible.
Energy
Energy
Not adjusting the margins—rethinking how energy is made, stored, and delivered. Work that will define the century.
Manufacturing
Manufacturing
The gap between breakthrough and production is where most deep tech dies. You are closing it—rebuilding domestic capacity in the systems, processes, and supply chains that turn science into scale.
Our Approach
We Look Where Complexity Hides Scale.
We stand with those who take on the hardest problems. Not those who avoid difficulty—those who are drawn to it.
The greatest opportunities rarely appear as such. They begin as empty ground: too regulated, too capital-intensive, too far from consensus. Overlooked—until someone with clarity and resolve proves their worth.
We look where consensus is not just cautious, but wrong. Where complexity hides scale. Where what appears uncertain is, in fact, enduring.
The forces that keep others away—difficulty, capital, time—are the very forces that protect the opportunity. They keep the field open, waiting for those prepared to begin and determined to finish.
In these domains, progress is not gradual. It comes in decisive advances. Those who succeed don't just improve the product—they change the terms of the market.
Capital matters. But demand is often the greater constraint. So we bring both. We do not wait for markets to form—we help bring them forward. Through relationships, partnerships, and pathways to procurement, we close the gap between what is possible and what is adopted.
That is where we work—at the point where possibility becomes reality.
Government-backed companies produced nearly 1 in 4 unicorns over the last twenty years. That tailwind is accelerating – and we’re positioning founders ahead of it.
Pitchbook, “US government helped create 24% of unicorns, study finds,” May 2025
Contact Us
If this sounds like you, email us at info@americasfrontier.com for more details.
Government-backed companies produced nearly 1 in 4 unicorns over the last twenty years. That tailwind is accelerating – and we’re positioning founders ahead of it.
Pitchbook, “US government helped create 24% of unicorns, study finds,” May 2025
The AFF Platform
The AFF Platform
01
Funds
Early to growth. Large opportunities, open fields.
01
Funds
Early to growth. Large opportunities, open fields.
02
Roadrunner
Turning technical breakthroughs into enduring companies—accelerating from lab to first product and first customer.
02
Roadrunner
Turning technical breakthroughs into enduring companies—accelerating from lab to first product and first customer.
03
Foundation
Relationships at the intersection of technology and policy. Access to where decisions are made, capital aligns with need, and ideas become real.
03
Foundation
Relationships at the intersection of technology and policy. Access to where decisions are made, capital aligns with need, and ideas become real.
Contact Us
If this sounds like you, email us at info@americasfrontier.com for more details.
Our Approach
We Look Where Complexity Hides Scale.
We stand with those who take on the hardest problems. Not those who avoid difficulty—those who are drawn to it.
The greatest opportunities rarely appear as such. They begin as empty ground: too regulated, too capital-intensive, too far from consensus. Overlooked—until someone with clarity and resolve proves their worth.
We look where consensus is not just cautious, but wrong. Where complexity hides scale. Where what appears uncertain is, in fact, enduring.
The forces that keep others away—difficulty, capital, time—are the very forces that protect the opportunity. They keep the field open, waiting for those prepared to begin and determined to finish.
In these domains, progress is not gradual. It comes in decisive advances. Those who succeed don't just improve the product—they change the terms of the market.
Capital matters. But demand is often the greater constraint. So we bring both. We do not wait for markets to form—we help bring them forward. Through relationships, partnerships, and pathways to procurement, we close the gap between what is possible and what is adopted.
That is where we work—at the point where possibility becomes reality.
Team
Brian Wilcove
Managing Partner
Gilman Louie
Managing Partner
Jeff Karras
General Partner
Steve Weinstein
General Partner
Marianne Winkler
CFO & General Partner
Kevin McGinnis
Partner
John Watters
Venture Partner
Aneesh Mdhekar
Analyst
Sabrina Rosahan
Executive Direcor, AFF
Brian Connor
Operations Manager
Mike Mettler
General Partner
Brian Wilcove
Managing Partner
Gilman Louie
Managing Partner
Jeff Karras
General Partner
Steve Weinstein
General Partner
Marianne Winkler
CFO & General Partner
Kevin McGinnis
Partner
John Watters
Venture Partner
Aneesh Mdhekar
Analyst
Sabrina Rosahan
Executive Direcor, AFF
Brian Connor
Operations Manager
Mike Mettler
General Partner
Portfolio
The Moment
Great Problems
Give Rise
to Great Markets.
This is a defining moment of global strategic competition—driven by accelerating revolutions in science and technology. It will be shaped not only by innovators, but by the investors who stand behind them.